Factors which affect erythropoiesis in partially nephrectomized and sham-operated rats

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Factors which affect erythropoiesis in partially nephrectomized and sham-operated rats.

Current concepts of the pathogenesis of anemia in uremic animals are derived mainly from the results of studies performed either in vitro or in bilaterally nephrectomized animals. These data may not be applicable to the situation which exists in more chronically uremic animals. In 1932, Chanutin and Ferris showed that removal of five-sixths of the renal mass caused rats to become uremic and to ...

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Glyoxalase activity in sham- and partially hepatectomized rats.

In male rats, hepatic glyoxalase activity and reduced glutathione, the cofactor for this enzyme system, approximately double 12 hr after partial (2/3) or sham hepatectomy, in which the liver lobes were handled during the sham operation. These changes precede by 10 to 12 hr the anticipated DNA synthesis after partial hepatectomy and by about 24 hr the smaller, but prolonged, DNA synthesis that o...

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Presence of toxic substances which inhibit erythropoiesis in serum of uremic nephrectomized rabbits.

The presence of toxic substances which inhibit erythropoiesis in uremic sera is still undetermined. We examined the effect of aceton-methylalcohol extracts of serum of nephrectomized rabbits with uremia on the erythropoiesis. The percentage red cell iron utilization was markedly reduced in nephrecto mized rabbits with uremia. The administration of aceton-methylalcohol extracts of uremic rabbit ...

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Factors which affect mortality in neonatal sepsis.

AIM Neonatal sepsis is an important cause of mortality and morbidity in newborns. The causative agents may be different in different units and may change in time. It was aimed to examine the microbiological agents leading to sepsis, clinical features and antibiotic resistances in babies with sepsis hospitalized in our unit in a two-year period. MATERIAL AND METHODS The clinical features, micr...

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The relationship between bone metabolism, melatonin and other hormones in sham-operated and pinealectomized rats.

OBJECTIVE The influence of pinealectomy and long-term melatonin (MEL) administration on circadian oscillations of selected biochemical markers of bone metabolism [serum alkaline phosphatase (ALP) activity, carboxyterminal propeptide type I procollagen (PICP) and carboxyterminal telopeptide type I collagen (ICTP) concentrations as well as urinary excretion of hydroxyproline (HYP) and Ca] and pos...

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ژورنال

عنوان ژورنال: Blood

سال: 1976

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood.v48.3.425.425